Phylogenetic analysis of HPAI H5N1 virus from duck swab specimens in Indonesia

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dc.contributor.authorMutisari, Dewi
dc.contributor.authorMuflihanah
dc.contributor.authorHendrawati, Ferra
dc.contributor.authorPutra, Hamdu Hamjaya
dc.contributor.authorSulistyo, Kartika Priscillia
dc.date.accessioned2021-10-13T06:15:02Z
dc.date.available2021-10-13T06:15:02Z
dc.date.issued2021-06
dc.description.abstractObjective: A phylogenetic study was carried out on the avian influenza virus (AIV) isolated from a disease outbreak in Sidenreng Rappang Regency, South Sulawesi, Indonesia, in 2018. Material and Methods: Oropharyngeal swabs and organ samples were obtained from ducks that showed clinical symptoms: torticollis, fascial edema, neurological disorders, the corneas appear cloudy, and death occurs less than 1 day after symptoms appear. In this study, isolate A/duck/ Sidenreng Rappang/07180110-11/2018 from duck was sequenced and characterized. Results: It was found that each gene segment of the virus has the highest nucleotide homology to the Indonesian highly pathogenic avian influenza (HPAI) H5N1 clade 2.3.2.1c. Multiple alignments of the sample Hemagglutinin (HA) gene with the avian influenza references virus showed that the pattern of amino acid arrangement in the cleavage site PQRERRRK-RGLF is the characteristic of the HPAI virus. In addition, the HA gene contained Q222 (glutamine) and G224 (glycine), signifying a high affinity to avian receptor binding specificity (SA α2,3 Gal). Furthermore, there was no genetic reassortment of this virus based on the phylogenetic analysis of HA, NA, PB1, PB2, PA, NP, M, and NS genes. Conclusion: The HPAI H5N1 clade 2.3.2.1c virus was identified in duck farms in South Sulawesi, Indonesia.en_US
dc.identifier.urihttps://repository.pertanian.go.id/handle/123456789/13773
dc.language.isoenen_US
dc.publisherPerpustakaan Balai Besar Veteriner Marosen_US
dc.subjectPhylogeneticen_US
dc.subjectHPAIen_US
dc.subjectH5N1en_US
dc.subjectducken_US
dc.subjectswaben_US
dc.subjectResearch Subject Categories::L Animal production/Produksi Hewan::L73 Animal diseases/Penyakit Hewanen_US
dc.titlePhylogenetic analysis of HPAI H5N1 virus from duck swab specimens in Indonesiaen_US
dc.typeBooken_US
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