Fowl Cholera and Its Control Prospect With Locally isolated Pasteurella multocida Bivalent Vaccines

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dc.creatorAriyanti, Tati
dc.creator., Supar
dc.date2008-03-01
dc.date.accessioned2018-06-04T07:49:13Z
dc.date.available2018-06-04T07:49:13Z
dc.descriptionPasteurellosis or fowl cholera disease which associated with Pasteurella multocida group A and D infections occurred sporadically in many parts of the world, including in Indonesia. The pathogenic activity of P. multocida in chickens were based on lipopolysacharide (LPS) antigens associated with group A and D capsules, and the resistance factor of complement mediated bacteriolysis in animals. In order to reduce common bacterial infections, antibiotics were routinely used as feed additive or by drinking water, but fowl cholera cases still occur. Fowl cholera control by vaccinations have been used more than a hundred years ago by means of inactive vaccine, but imported inactive vaccine was reported not effective due to lack of cross protection against heterologous serotype. At present, many  local P. multocida isolates from chicken and ducks from many  areas in Indonesia were characterised for their antigenicity, immunogenicity and prepared as monovalent or bivalent vaccine. Only the monovalent vaccine prepared from BCC 2331 or DY2 demonstrated the presence of immunoprotection against homologous and heterologous challenged with live bacteria. The prototype bivalent vaccine consisting of BCC 2331 + DY2 demonstrated high degree of cross protection against challenged individual with or mixed of BCC 2331 + DY2 at average of 60 – 75% and 75 – 100%, respectively. Monovalent and bivalent vaccine prepared from other isolates including imported reference strains of P. multocida demonstrated no protection in experimentally vaccinated ducks and chicken against challenged with live bacteria of neither BCC 2331 nor with DY2. From these retrospective studies, it was concluded that the local isolates P. multocida designated  as  BCC  2331  and  DY2  could  be  used  as candidates  of  prototype  vaccine  or  master  seed  vaccine  but their effectiveness still need to be evaluated under field conditions.  Key words: Pasteurella multocida, Indonesian isolates, inactive vaccines, fowl choleraen-US
dc.formatapplication/pdf
dc.identifierhttp://medpub.litbang.pertanian.go.id/index.php/wartazoa/article/view/908
dc.identifier10.14334/wartazoa.v18i1.908
dc.identifier.urihttps://repository.pertanian.go.id/handle/123456789/4600
dc.languageeng
dc.publisherIndonesian Center for Animal Research and Developmenten-US
dc.relationhttp://medpub.litbang.pertanian.go.id/index.php/wartazoa/article/view/908/917
dc.source2354-6832
dc.source0216-6461
dc.sourceWARTAZOA. Indonesian Bulletin of Animal and Veterinary Sciences; Vol 18, No 1 (2008): MARCH 2008; 18-24en-US
dc.titleFowl Cholera and Its Control Prospect With Locally isolated Pasteurella multocida Bivalent Vaccinesen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US
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