Pathological and biochemical changes in intoxication of mindi (Melia azedarach) leaf

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dc.contributoren-US
dc.creatorSani, Yulvian
dc.creatorBahri, Sjamsul
dc.date2014-02-25
dc.date.accessioned2018-06-04T06:47:47Z
dc.date.available2018-06-04T06:47:47Z
dc.date.issued2014-02-25
dc.descriptionThe purpose of this study was to investigate pathological and biochemical changes in intoxication of mindi leaf (Melia azedarach) on skeletal muscle and myocardial tissues . Fifty two male Wistar rats weighing 140 g to 240 g were intoxicated in 20%; 25% and 40% diet of mindi leaf ad libitwn for 25 days . Clinical signs did not appear the intoxication of mindi leaf. Specific pathological changes were not found macroscopically except cachexia and paleness . Skeletal muscle lesions on the other hand, were consistently noted microscopically . There were degeneration, necrosis and fragmentation of muscle fibres ; enlargement of nuclei ; fibrosis; oedema and hyalination . The hyalination was prominent and appeared to be more. progressive two weeks after dosing . Following the skeletal muscle lesions, myocardial showed degeneration, necrosis and fragmentation of fibres ; enlargement of nuclei and hypercellularity . Regeneration of skeletal muscle developed on day-5 after the substitution of mindi diet by normal diet indicated by disappearing of hyalin tissues . But, myocardial appeared to be regenerated two days after the substitution of diet . Enzymatic activities of alanine aminotransferase (ALAI) and aspartate aminotransferase (ASAT) were not affected. Both enzymes in treated animals were lower than the control . The substitution of diet showed an increased of enzymatic activities during the first two weeks of feeding then reduced at the subsequent weeks . However, these enzymes increased on day-3 after substitution and appeared to maximum followed by a reduction of enzymatic activities in week-4 . On the other hand, creatinine phosphokinase (CPK) was affected in which higher level was noted in treated groups than control . Substitution of diet has led to the reduction of cpc level on day-2 and appeared to reach the same level as in control group on day-21 . The control group was not affected either clinically, pathologically or biochemically . It remained normal throughout the experimental period .en-US
dc.formatapplication/pdf
dc.identifierhttp://medpub.litbang.pertanian.go.id/index.php/jitv/article/view/24
dc.identifier10.14334/jitv.v1i2.24
dc.identifier.urihttps://repository.pertanian.go.id/handle/123456789/3040
dc.languageeng
dc.publisherIndonesian Animal Sciences Societyen-US
dc.relationhttp://medpub.litbang.pertanian.go.id/index.php/jitv/article/view/24/24
dc.rightsCopyright (c) 1970 Indonesian Journal of Animal and Veterinary Sciencesen-US
dc.rightshttp://creativecommons.org/licenses/by/4.0en-US
dc.source2252-696X
dc.source0853-7380
dc.sourceIndonesian Journal of Animal and Veterinary Sciences; Vol 1, No 2 (1995); p.136-142en-US
dc.titlePathological and biochemical changes in intoxication of mindi (Melia azedarach) leafen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US
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