POTENCY OF ANTIOXIDANT, ANTICHOLESTEROL AND PLATELET ANTIAGGREGATION OF BLACK TEA (Camelia sinensis )

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dc.contributorBALAI PENELITIAN TANAMAN REMPAH DAN OBATen-US
dc.creatorWidowati, Wahyu
dc.creatorHerlina, Tati
dc.creatorRatnawati, Hana
dc.creatorMozef, Tjandrawati
dc.creatorImmanuel, Victor
dc.date2017-05-29
dc.date.accessioned2018-06-04T07:17:55Z
dc.date.available2018-06-04T07:17:55Z
dc.date.issued2011
dc.descriptionEpidemiological studies have shown an in-verse correlation betweendiets rich in po-lyphenols, flavonoids and reduced risk of cardiovasculardisease. These associationswere mainly ascribed to the antioxidant, antiaggregation and anticholesterol capa-city of polyphenols. This association has been explained that atherogenesis is ini-tiated by hypercholesterol, lipid peroxida-tion and hyper aggregation platelet. The research was carried out to evaluate anti-oxidant, anticholesterol and antiaggrega-tion activities of methanol extract and frac-tions of black tea (Camelia sinensis). To evaluate antioxidant activity of methanol extract and fractions were compared  with (-)-Epigallocatechine 3-gallate (EGCG), an-ticholesterol activity were compared with simvastatin and antiaggregation activity were compared with aspirin. Antioxidant activity using the 1,1-diphenyl-2-picryl-hy-drazyl (DPPH) free radical scavenging acti-vity at two concentrations 100 µg/mL, 50 µg/mL and anticholesterol was cholesterol oxidase activity at two concentrations 0.005 µg/mL, 0.0025 µg/mL, the antiag-gregation  activity  used epinephrine (EPN)agonist at two concentrations 300 μM, 75 μM and one concentration 37.1 µg/mL of methanol extract and fractions of black tea. To know the difference of treatment, the data were analysed using Analysis of Variance (ANOVA) and be continued Dun-can’s new multiple range test. The results showed that DPPH scavenging activity were high (88.59-93.556%), the anticho-lesterol showed high activity (93.663-97.434%) and the antiaggregation sho-wed low up to high activity (79.967-4.31%). Using Duncan’s new multiple ra-nge test showed that anti-oxidant activity were not different among extract and fractions of black tea,the highest anti-cholesterol activity was black tea extract 0.005 µg/mL (97.434%) and the highest antiaggregation activity was ethyl acetate fraction on 75 μM EPN agonist (4.310 %), water fraction 37.1 µg/mL with 300 μM EPN agonist (21.833%).en-US
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dc.identifierhttp://ejurnal.litbang.pertanian.go.id/index.php/bultro/article/view/1854
dc.identifier10.21082/bullittro.v22n1.2011.%p
dc.identifier.urihttps://repository.pertanian.go.id/handle/123456789/3692
dc.languageeng
dc.publisherPusat Penelitian dan Pengembangan Perkebunanen-US
dc.relationhttp://ejurnal.litbang.pertanian.go.id/index.php/bultro/article/view/1854/5607
dc.source2527-4414
dc.source0215-0824
dc.sourceBuletin Penelitian Tanaman Rempah dan Obat; Vol 22, No 1 (2011): BULETIN PENELITIAN TANAMAN REMPAH DAN OBAT; 74-83en-US
dc.sourceBuletin Penelitian Tanaman Rempah dan Obat; Vol 22, No 1 (2011): BULETIN PENELITIAN TANAMAN REMPAH DAN OBAT; 74-83id-ID
dc.subjecten-US
dc.titlePOTENCY OF ANTIOXIDANT, ANTICHOLESTEROL AND PLATELET ANTIAGGREGATION OF BLACK TEA (Camelia sinensis )en-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US
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