Effect of methanol extracts of nony fruit on mice infected by RH strain of Toxoplasma gondii

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dc.creatorSubekti, Didik T
dc.creatorSari, Eka S.P
dc.creatorWidiastuti, Dwi R
dc.creatorHaerlani, Rica
dc.creatorFitri Diani, Eka
dc.creatorIskandar, Tolibin
dc.creatorLaksmitawati, Dian R
dc.date2012-02-05
dc.date.accessioned2018-06-04T06:47:48Z
dc.date.available2018-06-04T06:47:48Z
dc.date.issued2012-02-05
dc.descriptionIntraperitoneal infection of Type I Toxoplasma gondii on mice causes high mortality at a short time due to parasitic burden, immunosuppression, cell and tissue damage. The mice survival is increased after treated with drugs that reduce or destroy tachyzoite and modulate or recovered the immune system. Nony fruit (Morinda citrifolia) is popular as immunomudulator and has antoxoplasma properties. The purpose of this experiment is to evaluate the effect of ethanol extract of nony fruit and Fansidar® (pyrimethamine-sulfadiazine) to reduce tachyzoite and improve survival as well as immunomudulator on mice following toxoplasma infection. Mice was divided into six groups (10 mice respectively) consist of infected-non treated groups, infected + Fansidar®, infected + ethanol extract of nony on several doses (100, 50, 25%) and non infected-non treated groups. All mice on each groups were infected intraperitoneally by 5 x 106 and 2,5 x 103 RH strain of Toxoplasma gondii tachyzoite/mice respectively. The results have shown that Fansidar® was successfully to reduced tachyzoite and improved mice survival but the ethanol extract of nony fruit was failed.     Key Words: Survivality, Immunomodulator, Toxoplasma gondii, Nony extractsen-US
dc.formatapplication/pdf
dc.identifierhttp://medpub.litbang.pertanian.go.id/index.php/jitv/article/view/457
dc.identifier10.14334/jitv.v10i4.457
dc.identifier.urihttps://repository.pertanian.go.id/handle/123456789/3048
dc.languageeng
dc.publisherIndonesian Animal Sciences Societyen-US
dc.relationhttp://medpub.litbang.pertanian.go.id/index.php/jitv/article/view/457/466
dc.rightsCopyright (c) 1970 Indonesian Journal of Animal and Veterinary Sciencesen-US
dc.rightshttp://creativecommons.org/licenses/by/4.0en-US
dc.source2252-696X
dc.source0853-7380
dc.sourceIndonesian Journal of Animal and Veterinary Sciences; Vol 10, No 4 (2005): DECEMBER 2005; p.305-314en-US
dc.titleEffect of methanol extracts of nony fruit on mice infected by RH strain of Toxoplasma gondiien-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US
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