Extrahepatic bile duct ligation in broiler chickens: ultrastructural study of Ito cell

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dc.creatorHandharyani, Ekowati
dc.creatorOchiai, K
dc.creatorWinarto, A
dc.date2014-02-21
dc.date.accessioned2018-06-04T06:48:38Z
dc.date.available2018-06-04T06:48:38Z
dc.date.issued2014-02-21
dc.descriptionThe Ito cell (fat-storing cell) is a cell lying in perisinusoidal space of liver. The function of Ito cell is expanding from a site of fat-storing site to a center of extracellular matrix metabolism and mediator production in the liver. This study was performed in order to evaluate the Ito cells in cholestatic condition. The artificial cholestatic was conducted by ligation of extrahepatic bile ducts (bile duct ligation = BDL) in broilers. The results showed that BDL induced bile congestion, fibrosis, proliferation of Ito cells and intrahepatic bile ductules. Immunohistochemistry demonstrated that Ito cells were scattered throughout the fibrotic areas, and larger in size with more extensive immunoreactivity than those in normal livers. Ultrastructural study demonstrated that Ito cells were closely associated with the production of extracellular collagen fibers. Ito cells actively react against hepatocytic injuries, especially in fibrogenesis of cholestatic livers.   Key words: Bile duct, ito cell, broileren-US
dc.formatapplication/pdf
dc.identifierhttp://medpub.litbang.pertanian.go.id/index.php/jitv/article/view/435
dc.identifier10.14334/jitv.v9i4.435
dc.identifier.urihttps://repository.pertanian.go.id/handle/123456789/3412
dc.languageeng
dc.publisherIndonesian Animal Sciences Societyen-US
dc.relationhttp://medpub.litbang.pertanian.go.id/index.php/jitv/article/view/435/444
dc.rightsCopyright (c) 2014 Indonesian Journal of Animal and Veterinary Sciencesen-US
dc.rightshttp://creativecommons.org/licenses/by/4.0en-US
dc.source2252-696X
dc.source0853-7380
dc.sourceIndonesian Journal of Animal and Veterinary Sciences; Vol 9, No 4 (2004): DECEMBER 2004; p.252-257en-US
dc.titleExtrahepatic bile duct ligation in broiler chickens: ultrastructural study of Ito cellen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US
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