In vitro studies: The role of immunological cells in Indonesian thin tail sheep in the killing of the liver fluke, Fasciola

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dc.creator Estuningsih, S.E
dc.creator Wiidjajanti, S
dc.creator Partoutomo, S
dc.creator ., Spithill
dc.creator Raadsma, H
dc.creator Piedrafita, D
dc.date 2014-02-17
dc.date.accessioned 2018-06-04T06:47:02Z
dc.date.available 2018-06-04T06:47:02Z
dc.date.issued 2014-02-17
dc.identifier http://medpub.litbang.pertanian.go.id/index.php/jitv/article/view/284
dc.identifier 10.14334/jitv.v7i2.284
dc.identifier.uri http://repository.pertanian.go.id/handle/123456789/2716
dc.description Previous studies have shown that Indonesian Thin Tail (ET) sheep exhibit high resistance to challenge with Fasciola gigantica when compared with Merino sheep, and this resistance is expressed in early infection. In order to study the role of the immune system in this resistance to ET sheep, in vitro studies were undertaken in the laboratory. In vitro study to confirm the ability of immune cells from ET sheep in the killing of F. gigantica larvae has been done by incubating immune cells and F. gigantica larvae together with immune sera or normal sera. The viability of the larvae was observed over a period 3 days incubation by observing their motility. The results showed that the cells isolated from F. gigantica- challenged ET sheep in the presence of immune sera from ET were able to kill 70% of the larvae. In contrast, cells from infected Merino were unable to kill a significant number of F. gigantica using the same sera source. It seems that the cytotoxicity was dependent on the presence of immune sera and ET peritoneal cells, suggesting the potential role of an antibody-dependent cell cytotoxic (ADCC) mechanism in the resistant ET sheep. Key words: In vitro, Fasciola gigantica, peritoneal cell, sheep gigantica. en-US
dc.format application/pdf
dc.language eng
dc.publisher Indonesian Animal Sciences Society en-US
dc.relation http://medpub.litbang.pertanian.go.id/index.php/jitv/article/view/284/284
dc.rights Copyright (c) 1970 Indonesian Journal of Animal and Veterinary Sciences en-US
dc.rights http://creativecommons.org/licenses/by/4.0 en-US
dc.source 2252-696X
dc.source 0853-7380
dc.source Indonesian Journal of Animal and Veterinary Sciences; Vol 7, No 2 (2002): JUNE 2002; p.124-129 en-US
dc.title In vitro studies: The role of immunological cells in Indonesian thin tail sheep in the killing of the liver fluke, Fasciola en-US
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion
dc.type Peer-reviewed Article en-US


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