Effects of Silybum marianum Aqueous Extract and L-carnitine on Stereological Changes in Diazinon-Treated Rat Liver

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dc.contributor en-US
dc.creator Masoumi, Forough; Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
dc.creator Shariati, Mehrdad; Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun
dc.creator Mokhtari, Mokhtar; Department of Biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
dc.date 2020-06-10
dc.date.accessioned 2020-11-06T02:28:26Z
dc.date.available 2020-11-06T02:28:26Z
dc.identifier http://medpub.litbang.pertanian.go.id/index.php/jitv/article/view/2467
dc.identifier 10.14334/jitv.v25i2.2467
dc.identifier.uri http://repository.pertanian.go.id/handle/123456789/10425
dc.description As an organophosphorus, Diazinon (DZN) impairs liver tissue function by inhibiting acetylcholinesterase and causing oxidative stress. In this study, the effects of Silybum marianum aqueous extract (SMAE) and L-carnitine (LC) on the stereological and histopathological changes of the liver in DZN-treated male rats were investigated. The rats in this study were placed into 9 groups of 8 each containing control, placebo, and a combination of DZN, SMAE, and LC. The animals received SMAE and chemicals orally for 30 days. At last, the liver tissue of all animals was removed. Then, tissue sections from the liver were provided to study the stereological markers including liver volume and weight, hepatocytes’ volume, central venous volume, sinusoidal volume, connective tissue volume, inflammation rate, and a number of the hepatocytes’ nuclei. Also, the sample tissues were evaluated histopathologically. Treatment with DZN significantly reduced the liver volume and weight, hepatocyte volume, central venous volume, sinusoidal volume, and hepatocyte nucleus number compared to placebo and control but it significantly increased the inflammation and volume of liver’s connective tissue. However, co-administration of SMAE and LC with DZN improved liver volume and weight, hepatocyte volume, central venous volume, sinusoidal volume, connective tissue volume, and hepatocyte nucleus number alone compared to the DZN treatment. Liver inflammation was also significantly decreased compared to the DZN treatment but comparing to the placebo and control groups, it increased significantly. Simultaneous administration of SMAE and LC has protective effects on liver tissue and can reduce DZN-induced liver injury in rats. en-US
dc.format application/pdf
dc.language eng
dc.publisher Indonesian Center for Animal Research and Development (ICARD) en-US
dc.relation http://medpub.litbang.pertanian.go.id/index.php/jitv/article/view/2467/2160
dc.relation http://medpub.litbang.pertanian.go.id/index.php/jitv/article/downloadSuppFile/2467/162
dc.relation http://medpub.litbang.pertanian.go.id/index.php/jitv/article/downloadSuppFile/2467/164
dc.relation http://medpub.litbang.pertanian.go.id/index.php/jitv/article/downloadSuppFile/2467/165
dc.relation http://medpub.litbang.pertanian.go.id/index.php/jitv/article/downloadSuppFile/2467/166
dc.relation http://medpub.litbang.pertanian.go.id/index.php/jitv/article/downloadSuppFile/2467/167
dc.rights Copyright (c) 2020 Jurnal Ilmu Ternak dan Veteriner en-US
dc.source Jurnal Ilmu Ternak dan Veteriner; Vol 25, No 2 (2020): JUNE 2020; 91-98 en-US
dc.source 2252-696X
dc.source 0853-7380
dc.subject Diazinon, L-carnitine, Liver, Rat, Silybum marianum en-US
dc.title Effects of Silybum marianum Aqueous Extract and L-carnitine on Stereological Changes in Diazinon-Treated Rat Liver en-US
dc.type info:eu-repo/semantics/article
dc.type info:eu-repo/semantics/publishedVersion
dc.type Peer-reviewed Article en-US


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